The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

The amoeba-resistant bacterium Legionella pneumophila causes Legionnaires’ disease and employs a type IV secretion system (T4SS) to replicate in the unique, ER-associated Legionella-containing vacuole (LCV). The large fusion GTPase Sey1/atlastin is implicated in ER dynamics, ER-derived lipid droplet...

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Bibliographic Details
Main Authors: Dario Hüsler, Pia Stauffer, Bernhard Keller, Desirée Böck, Thomas Steiner, Anne Ostrzinski, Simone Vormittag, Bianca Striednig, A Leoni Swart, François Letourneur, Sandra Maaß, Dörte Becher, Wolfgang Eisenreich, Martin Pilhofer, Hubert Hilbi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
host-pathogen interaction
intracellular bacteria
large GTPase
Legionella
lipid droplet
pathogen vacuole
Online Access:https://elifesciences.org/articles/85142

Internet

https://elifesciences.org/articles/85142

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