1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies

1,2,3-triazole and chiral Schiff base hybrids as potential anticancer agents: DFT, molecular docking and ADME studies

Abstract A series of novel 1,2,3-triazole and chiral Schiff base hybrids 2–6 were synthesized by Schiff base condensation reaction from pre-prepared parent component of the hybrids (1,2,3-triazole 1) and series of primary chiral amines and their chemical structure were confirmed using NMR and FTIR s...

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Bibliographic Details
Main Authors: Yonas Belay, Alfred Muller, Fanikie S. Mokoena, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Cancer
Hybrid drugs
1,2,3-triazole
Chiral Schiff bases
Molecular docking
ADME
Online Access:https://doi.org/10.1038/s41598-024-57689-5

Internet

https://doi.org/10.1038/s41598-024-57689-5

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