Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach

Searching for novel MDM2/MDMX dual inhibitors through a drug repurposing approach

AbstractDisruption of p53-MDM2/MDMX interaction by smaller inhibitors is a promising therapeutic intervention gaining tremendous interest. However, no MDM2/MDMX inhibitors have been marketed so far. Drug repurposing is a validated, practical approach to drug discovery. In this regard, we employed st...

Full description

Bibliographic Details
Main Authors: Keting Li, Wenshu Hu, Yingjie Wang, Wenxing Chen, Hongmei Wen, Jian Liu, Wei Li, Bo Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Drug repurposing
MDM2/MDMX
p53
nintedanib
dual inhibitors
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2288810

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2288810

Similar Items