Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein

Repurposing of berbamine hydrochloride to inhibit Ebola virus by targeting viral glycoprotein

Ebola virus (EBOV) infection leads to staggeringly high mortality rate. Effective and low-cost treatments are urgently needed to control frequent EBOV outbreaks in Africa. In this study, we report that a natural compound called berbamine hydrochloride strongly inhibits EBOV replication in vitro and...

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Bibliographic Details
Main Authors: Dongrong Yi, Quanjie Li, Han Wang, Kai Lv, Ling Ma, Yujia Wang, Jing Wang, Yongxin Zhang, Mingliang Liu, Xiaoyu Li, Jianxun Qi, Yi Shi, George F. Gao, Shan Cen
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Ebola virus
Drug repositioning
Entry inhibitor
Primed glycoprotein
Structure-based virtual screening
Protein–protein interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522002453

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http://www.sciencedirect.com/science/article/pii/S2211383522002453

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