Upregulation of proteolytic enzymes and cyclooxygenase-2 in human gingival fibroblasts stimulated with safrole

Background/purpose: Areca quid chewing is associated with periodontal diseases. Many of the undesirable effects of areca quid have been attributed to safrole, a major polyphenolic compound in the inflorescence of Piper betle. Matrix metalloproteinases (MMPs, a subclass of proteolytic enzymes), plasm...

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Bibliographic Details
Main Authors: Yung-Chuan Ho, Ching-Chih Chen, Shun-Fa Yang, Fu-Mei Huang, Yu-Chao Chang
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Journal of Dental Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S199179021300024X