Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data.

Application of transfer learning to predict drug-induced human in vivo gene expression changes using rat in vitro and in vivo data.

The liver is the primary site for the metabolism and detoxification of many compounds, including pharmaceuticals. Consequently, it is also the primary location for many adverse reactions. As the liver is not readily accessible for sampling in humans; rodent or cell line models are often used to eval...

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Bibliographic Details
Main Authors: Shauna D O'Donovan, Rachel Cavill, Florian Wimmenauer, Alexander Lukas, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Kurt Driessens, Ralf L M Peeters, Theo M C M de Kok
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292030&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0292030&type=printable

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