In silico advancements in Peptide-MHC interaction: A molecular dynamics study of predicted glypican-3 peptides and HLA-A*11:01

In silico advancements in Peptide-MHC interaction: A molecular dynamics study of predicted glypican-3 peptides and HLA-A*11:01

Our study employed molecular dynamics (MD) simulations to assess the binding affinity between short peptides derived from the tumor-associated antigen glypican 3 (GPC3) and the major histocompatibility complex (MHC) molecule HLA-A*11:01 in hepatocellular carcinoma. We aimed to improve the reliabilit...

Full description

Bibliographic Details
Main Authors: Thaweesak Chieochansin, Kamonpan Sanachai, Nitchakan Darai, Wannasiri Chiraphapphaiboon, Kornkan Choomee, Pa-thai Yenchitsomanus, Chanitra Thuwajit, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Heliyon
Subjects:
Molecular dynamics simulation
Binding ability
Predicted glypican-3 peptides
Human leukocyte antigen-A*11:01
Hepatocellular carcinoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024126850

Internet

http://www.sciencedirect.com/science/article/pii/S2405844024126850

Similar Items