Targeted genome mining for microbial antitumor agents acting through DNA intercalation

Targeted genome mining for microbial antitumor agents acting through DNA intercalation

Microbial natural products have been one of the most important sources for drug development. In the current postgenomic era, sequence-driven approaches for natural product discovery are becoming increasingly popular. Here, we develop an effective genome mining strategy for the targeted discovery of...

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Bibliographic Details
Main Authors: Zhijie Zhao, Guiyun Zhao, Yi Chai, Wei Li, Kaihui Song, Wenbin Zhao, Hairong Li, Miaolian Wu, Zhan Zhou, Yi-Ling Du
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-09-01
Series:Synthetic and Systems Biotechnology
Subjects:
Genome mining
Microbial natural product
DNA intercalator
UvrA-like protein
Biosynthetic gene clusters
Tetracycline
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X23000571

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http://www.sciencedirect.com/science/article/pii/S2405805X23000571

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