Delivery of therapeutic small interfering RNA: The current patent-based landscape
Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery systems containing key technologies have been...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253122001639 |
| _version_ | 1818532843981111296 |
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| author | Yu Chen Shi-Hang Xiong Fei Li Xiang-Jun Kong De-Fang Ouyang Ying Zheng Hua Yu Yuan-Jia Hu |
| author_facet | Yu Chen Shi-Hang Xiong Fei Li Xiang-Jun Kong De-Fang Ouyang Ying Zheng Hua Yu Yuan-Jia Hu |
| author_sort | Yu Chen |
| collection | DOAJ |
| description | Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery systems containing key technologies have been developed and patented, which are of great concern to developers in the field. Despite numerous studies devoted to siRNA-delivery technologies, few researchers have systematically examined relevant patents. Patents, as bridges connecting academic progress with applicable innovation, encapsulate cumulative technological innovations and provide valuable information for academic research and commercial development. This study aims to analyze advances in therapeutic siRNA delivery technology from a patent perspective. A total of 11,509 patent documents from 3,309 patent families were collected, classified into 10 technological categories, and comprehensively analyzed. An overall patent landscape of siRNA delivery was presented from the temporal, spatial, organizational, and technological dimensions. This work is expected to help researchers and developers in the field of siRNA delivery form a basis for decision-making by combining our findings with supplementary data. |
| first_indexed | 2024-12-11T17:50:49Z |
| format | Article |
| id | doaj.art-658bd279af294175a541059e910a09b4 |
| institution | Directory Open Access Journal |
| issn | 2162-2531 |
| language | English |
| last_indexed | 2024-12-11T17:50:49Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Nucleic Acids |
| spelling | doaj.art-658bd279af294175a541059e910a09b42022-12-22T00:56:13ZengElsevierMolecular Therapy: Nucleic Acids2162-25312022-09-0129150161Delivery of therapeutic small interfering RNA: The current patent-based landscapeYu Chen0Shi-Hang Xiong1Fei Li2Xiang-Jun Kong3De-Fang Ouyang4Ying Zheng5Hua Yu6Yuan-Jia Hu7State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China; Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China; Corresponding author Hua Yu, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China; Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China; Corresponding author Yuan-Jia Hu, State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery systems containing key technologies have been developed and patented, which are of great concern to developers in the field. Despite numerous studies devoted to siRNA-delivery technologies, few researchers have systematically examined relevant patents. Patents, as bridges connecting academic progress with applicable innovation, encapsulate cumulative technological innovations and provide valuable information for academic research and commercial development. This study aims to analyze advances in therapeutic siRNA delivery technology from a patent perspective. A total of 11,509 patent documents from 3,309 patent families were collected, classified into 10 technological categories, and comprehensively analyzed. An overall patent landscape of siRNA delivery was presented from the temporal, spatial, organizational, and technological dimensions. This work is expected to help researchers and developers in the field of siRNA delivery form a basis for decision-making by combining our findings with supplementary data.http://www.sciencedirect.com/science/article/pii/S2162253122001639therapeutic siRNAdelivery technologypatent landscape |
| spellingShingle | Yu Chen Shi-Hang Xiong Fei Li Xiang-Jun Kong De-Fang Ouyang Ying Zheng Hua Yu Yuan-Jia Hu Delivery of therapeutic small interfering RNA: The current patent-based landscape Molecular Therapy: Nucleic Acids therapeutic siRNA delivery technology patent landscape |
| title | Delivery of therapeutic small interfering RNA: The current patent-based landscape |
| title_full | Delivery of therapeutic small interfering RNA: The current patent-based landscape |
| title_fullStr | Delivery of therapeutic small interfering RNA: The current patent-based landscape |
| title_full_unstemmed | Delivery of therapeutic small interfering RNA: The current patent-based landscape |
| title_short | Delivery of therapeutic small interfering RNA: The current patent-based landscape |
| title_sort | delivery of therapeutic small interfering rna the current patent based landscape |
| topic | therapeutic siRNA delivery technology patent landscape |
| url | http://www.sciencedirect.com/science/article/pii/S2162253122001639 |
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