Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy

Effects of mutant lamins on nucleo-cytoskeletal coupling in Drosophila models of LMNA muscular dystrophy

The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear membrane. Lamins play a myriad of roles, inclu...

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Bibliographic Details
Main Authors: Nicholas M. Shaw, Jose L. Rios-Monterrosa, Gregory R. Fedorchak, Margaret R. Ketterer, Gary S. Coombs, Jan Lammerding, Lori L. Wallrath
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
myonuclei
muscular dystrophies
Drosophila
lamins
LINC complex
microtubules
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.934586/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.934586/full

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