Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole–Pyrimidine Derivatives as Potential Antiproliferative Agents

Design and Synthesis of New 4-(3,4,5-Trimethoxyphenyl)Thiazole–Pyrimidine Derivatives as Potential Antiproliferative Agents

A new series of 3,4,5-trimethoxyphenyl thiazole pyrimidines has been synthesized and biologically evaluated for its in vitro anticancer activity. Compounds <b>4a</b>, <b>4b</b>, and <b>4h</b> with substituted piperazine showed the best antiproliferative activity....

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Bibliographic Details
Main Authors: Ashraf K. El-Damasy, Heewon Jin, Mohamed A. Sabry, Hyun Ji Kim, Mohammed M. Alanazi, Seon Hee Seo, Eun-Kyoung Bang, Gyochang Keum
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Medicina
Subjects:
trimethoxyphenyl
thiazole
pyrimidines
NCI-60 screening
NSCL cancer cell line
ADME-Tox prediction
Online Access:https://www.mdpi.com/1648-9144/59/6/1076

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https://www.mdpi.com/1648-9144/59/6/1076

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