Role and mechanism of fibroblast-activated protein-α expression on the surface of fibroblast-like synoviocytes in rheumatoid arthritis

Role and mechanism of fibroblast-activated protein-α expression on the surface of fibroblast-like synoviocytes in rheumatoid arthritis

Fibroblast-activated protein-α (FAP) is a type II integrated serine protease expressed by activated fibroblasts during fibrosis or inflammation. Fibroblast-like synoviocytes (FLSs) in rheumatoid arthritis (RA) synovial sites abundantly and stably overexpress FAP and play important roles in regulatin...

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Bibliographic Details
Main Authors: Zihan Wang, Jinping Wang, Tianyi Lan, Liubo Zhang, Zeran Yan, Nan Zhang, Yuan Xu, Qingwen Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
fibroblast-activated protein-α
fibroblast-like synoviocytes
cell function
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135384/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1135384/full

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