Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease

<p>Abstract</p> <p>Background</p> <p>One of the best-characterized causative factors of Alzheimer’s disease (AD) is the generation of amyloid-β peptide (Aβ). AD subjects are at high risk of epileptic seizures accompanied by aberrant neuronal excitability, which in itsel...

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Bibliographic Details
Main Authors: Saito Yuhki, Inoue Tsuyoshi, Zhu Gang, Kimura Naoki, Okada Motohiro, Nishimura Masaki, Kimura Nobuyuki, Murayama Shigeo, Kaneko Sunao, Shigemoto Ryuichi, Imoto Keiji, Suzuki Toshiharu
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/7/1/50

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http://www.molecularneurodegeneration.com/content/7/1/50

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