Discrimination of SARS-CoV-2 omicron variant and its lineages by rapid detection of immune-escape mutations in spike protein RBD using asymmetric PCR-based melting curve analysis

Discrimination of SARS-CoV-2 omicron variant and its lineages by rapid detection of immune-escape mutations in spike protein RBD using asymmetric PCR-based melting curve analysis

Abstract Background The SARS-CoV-2 Omicron strain has multiple immune-escape mutations in the spike protein receptor-binding domain (RBD). Rapid detection of these mutations to identify Omicron and its lineages is essential for guiding public health strategies and patient treatments. We developed a...

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Bibliographic Details
Main Authors: Xiaomu Kong, Peng Gao, Yongwei Jiang, Lixia Lu, Meimei Zhao, Yi Liu, Guoxiong Deng, Haoyan Zhu, Yongtong Cao, Liang Ma
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Virology Journal
Subjects:
Omicron
Mutation detection
Asymmetric PCR
Melting curve analysis
SARS-CoV-2
Online Access:https://doi.org/10.1186/s12985-023-02137-5

Internet

https://doi.org/10.1186/s12985-023-02137-5

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