Novel Diagnostic and Therapeutic Options for KMT2A-Rearranged Acute Leukemias

Novel Diagnostic and Therapeutic Options for KMT2A-Rearranged Acute Leukemias

The KMT2A (MLL) gene rearrangements (KMT2A-r) are associated with a diverse spectrum of acute leukemias. Although most KMT2A-r are restricted to nine partner genes, we have recently revealed that KMT2A-USP2 fusions are often missed during FISH screening of these genetic alterations. Therefore, compl...

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Bibliographic Details
Main Authors: Bruno A. Lopes, Caroline Pires Poubel, Cristiane Esteves Teixeira, Aurélie Caye-Eude, Hélène Cavé, Claus Meyer, Rolf Marschalek, Mariana Boroni, Mariana Emerenciano
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
KMT2A
MLL
acute leukemia
biomarker
machine learning
therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.749472/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.749472/full

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