Revisiting Telomere Shortening in Cancer

Telomeres, the protective structures of chromosome ends are gradually shortened by each cell division, eventually leading to senescence or apoptosis. Cancer cells maintain the telomere length for unlimited growth by telomerase reactivation or a recombination-based mechanism. Recent genome-wide analy...

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Bibliographic Details
Main Authors: Keiji Okamoto, Hiroyuki Seimiya
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/8/2/107