Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity

Abstract Myocardial regeneration capacity declines during the first week after birth, and this decline is linked to adaptation to oxidative metabolism. Utilizing this regenerative window, we characterized the metabolic changes in myocardial injury in 1-day-old regeneration-competent and 7-day-old re...

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Bibliographic Details
Main Authors: E. Kankuri, P. Finckenberg, J. Leinonen, M. Tarkia, S. Björk, J. Purhonen, J. Kallijärvi, M. Kankainen, R. Soliymani, M. Lalowski, E. Mervaala
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-00967-5