Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer

Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer

Abstract Background To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors. Methods The BrdU assay, Annexin-V/PI assay, TRAP staining and immunofluorescence were perfo...

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Bibliographic Details
Main Authors: Jin Qian, Zi-chen Gong, Yi-na Zhang, Hong-hua Wu, Jing Zhao, Li-ting Wang, Li-juan Ye, Da Liu, Wei Wang, Xia Kang, Jun Sheng, Wei Xu, Xi-lin Liu, Juan Wu, Wei Zheng
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Cell Communication and Signaling
Subjects:
Lactic acid
Bone metastasis
Osteoclast precursors
CXCL10
Cadherin-11
PI3K-AKT pathway
Online Access:https://doi.org/10.1186/s12964-020-00667-x

Internet

https://doi.org/10.1186/s12964-020-00667-x

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