Nano‐Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury

Nano‐Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury

Abstract Toll‐like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of acute lung injury (ALI). While TLR inhibition is a promising strategy to control the overwhelming inflammation in ALI, there still lacks effective TLR inhibitors for clinical uses to date. A uniq...

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Bibliographic Details
Main Authors: Liya Sun, Yuan Liu, Xiali Liu, Rui Wang, Jiameng Gong, Aabida Saferali, Wei Gao, Aying Ma, Huiqiang Ma, Stuart E. Turvey, Shan‐Yu Fung, Hong Yang
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Advanced Science
Subjects:
acute lung injury
bioactive nanoparticles
drug repurposing
inflammation
macrophages
proton pump inhibitors
Online Access:https://doi.org/10.1002/advs.202104051

Internet

https://doi.org/10.1002/advs.202104051

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