Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients

Bioenergetic and Metabolic Impairments in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Generated from Duchenne Muscular Dystrophy Patients

Duchenne muscular dystrophy (DMD) is caused by mutations in the <i>dystrophin</i> gene and dilated cardiomyopathy (DCM) is a major cause of morbidity and mortality in DMD patients. We tested the hypothesis that DCM is caused by metabolic impairments by employing induced pluripotent stem...

Full description

Bibliographic Details
Main Authors: Lubna Willi, Ifat Abramovich, Jonatan Fernandez-Garcia, Bella Agranovich, Margarita Shulman, Helena Milman, Polina Baskin, Binyamin Eisen, Daniel E. Michele, Michael Arad, Ofer Binah, Eyal Gottlieb
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
DMD
iPSC-CMs
bioenergetics
metabolism
electrophysiology
Online Access:https://www.mdpi.com/1422-0067/23/17/9808

Internet

https://www.mdpi.com/1422-0067/23/17/9808

Similar Items