NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression

NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression

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Signaling driven by nucleic acid sensors participates in interferonopathy-mediated autoimmune diseases. NLRP12, a pyrin-containing NLR protein, is a negative regulator of innate immune activation and type I interferon (IFN-I) production. Peripheral blood mononuclear cells (PBMCs) derived from system...

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Bibliographic Details
Main Authors: Yen-Po Tsao, Fang-Yu Tseng, Chih-Wei Chao, Ming-Han Chen, Yi-Chen Yeh, Babamale Olarewaju Abdulkareem, Se-Yi Chen, Wen-Ting Chuang, Pei-Ching Chang, I-Chun Chen, Pin-Hsuan Wang, Chien-Sheng Wu, Chang-Youh Tsai, Szu-Ting Chen
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-04-01
Series:The Journal of Clinical Investigation
Subjects:
Autoimmunity
Inflammation
Online Access:https://doi.org/10.1172/JCI157272

Internet

https://doi.org/10.1172/JCI157272

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