Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy

Polymorphism in autophagy-related genes LRP1 and CAPZA1 may promote gastric mucosal atrophy

Abstract Background Helicobacter pylori secretes cytotoxin-associated gene A (CagA) into the gastric epithelium, causing gastric mucosal atrophy (GMA) and gastric cancer. In contrast, host cells degrade CagA via autophagy. However, the association between polymorphisms in autophagy-related genes and...

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Bibliographic Details
Main Authors: Naoyuki Yamaguchi, Takuki Sakaguchi, Hajime Isomoto, Tatsuo Inamine, Ryoya Tsukamoto, Daisuke Fukuda, Ken Ohnita, Tsutomu Kanda, Kayoko Matsushima, Tatsuro Hirayama, Kazuo Yashima, Kazuhiro Tsukamoto
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Genes and Environment
Subjects:
Cytotoxin-associated gene A
Gastric mucosal atrophy
Autophagy-related genes
LRP1
CAPZA1
LAMP1
Online Access:https://doi.org/10.1186/s41021-023-00274-5

Internet

https://doi.org/10.1186/s41021-023-00274-5

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