Modulation of the Cytotoxic Properties of Pd(II) Complexes Based on Functionalized Carboxamides Featuring Labile Phosphoryl Coordination Sites

Modulation of the Cytotoxic Properties of Pd(II) Complexes Based on Functionalized Carboxamides Featuring Labile Phosphoryl Coordination Sites

Platinum-based drugs are commonly recognized as a keystone in modern cancer chemotherapy. However, intrinsic and acquired resistance as well as serious side effects often caused by the traditional Pt(II) anticancer agents prompt a continuous search for more selective and efficient alternatives. Toda...

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Bibliographic Details
Main Authors: Diana V. Aleksanyan, Aleksandr V. Konovalov, Svetlana G. Churusova, Ekaterina Yu. Rybalkina, Alexander S. Peregudov, Svetlana A. Aksenova, Evgenii I. Gutsul, Zinaida S. Klemenkova, Vladimir A. Kozlov
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
palladium
(aminoalkyl)phosphine oxides
bi- and tridentate ligands
anticancer activity
metal-based cytotoxic agents
Online Access:https://www.mdpi.com/1999-4923/15/4/1088

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https://www.mdpi.com/1999-4923/15/4/1088

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