Single-cell analysis reveals the COL11A1+ fibroblasts are cancer-specific fibroblasts that promote tumor progression

Single-cell analysis reveals the COL11A1+ fibroblasts are cancer-specific fibroblasts that promote tumor progression

Background: Cancer-associated fibroblasts (CAFs) promote tumor progression through extracellular matrix (ECM) remodeling and extensive communication with other cells in tumor microenvironment. However, most CAF-targeting strategies failed in clinical trials due to the heterogeneity of CAFs. Hence, w...

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Bibliographic Details
Main Authors: Jiayu Zhang, Shiqi Lu, Tong Lu, Donghui Han, Keying Zhang, Lunbiao Gan, Xinjie Wu, Yu Li, Xiaolong Zhao, Zhengxuan Li, Yajie Shen, Sijun Hu, Fa Yang, Weihong Wen, Weijun Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
cancer-associated fibroblasts
single-cell RNA sequencing
tumor microenvironment
ECM remodeling
immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1121586/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1121586/full

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