Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction

Mitochondrial protein acetylation is associated with a host of diseases including cancer, Alzheimer’s, and metabolic syndrome. Deciphering the mechanisms regarding how protein acetylation contributes to disease pathologies remains difficult due to the complex diversity of pathways targeted by lysine...

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Bibliographic Details
Main Authors: Courtney D. McGinnis, Erin Q. Jennings, Peter S. Harris, James J. Galligan, Kristofer S. Fritz
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
acetylation
sirtuin
histone deacetylase
mitochondria
non-alcoholic liver disease
metabolic syndrome
Online Access:https://www.mdpi.com/2073-4409/11/13/2045

Internet

https://www.mdpi.com/2073-4409/11/13/2045

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