RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy

RAB18 regulates extrahepatic siRNA-mediated gene silencing efficacy

Small interfering RNAs (siRNAs) hold considerable therapeutic potential to selectively silence previously “undruggable” disease-associated targets, offering new opportunities to fight human diseases. This therapeutic strategy, however, is limited by the inability of naked siRNAs to passively diffuse...

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Bibliographic Details
Main Authors: Jiamiao Lu, Jasper Lee, Eric Yuan, Devin L. Wakefield, Matt Kanke, Danielle Pruitt, Jose Barreda, Ingrid C. Rulifson, Jiansong Xie, John Ferbas, Jason Long, Bryan Meade, Oliver Homann, Wei Guo, Tina Gomes, Hong Zhou, Bin Wu, Jixin Cui, Songli Wang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
RAB18
siRNA
siRNA trafficking
extrahepatic
lipid droplets
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253124002221

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http://www.sciencedirect.com/science/article/pii/S2162253124002221

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