The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas

The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas

Abstract Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to TLR3 triggers a pro-inflammatory cascade leading to cytokine release and immune cell activation. Its anti-tumoral...

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Bibliographic Details
Main Authors: Joseph Bisaccia, Swann Meyer, Adrien Bertrand-Chapel, Quentin Hecquet, Virginie Barbet, Bastien Kaniewski, Sophie Léon, Nicolas Gadot, Isabelle Rochet, Iveta Fajnorova, Pierre Leblond, Martine Cordier-Bussat, Nadège Corradini, Alexandre Vasiljevic, Marc Billaud, Cécile Picard, Laura Broutier, Cindy Gallerne, Aurélie Dutour, Jean-Yves Blay, Marie Castets
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01513-y

Internet

https://doi.org/10.1038/s41420-023-01513-y

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