Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity

Simultaneous inhibition of more than one target is considered to be a novel strategy in cancer therapy. Owing to the importance of histone deacetylases (HDACs) and p53-murine double minute 2 (MDM2) interaction in tumor development and their synergistic effects, a series of MDM2/HDAC bifunctional sma...

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Bibliographic Details
Main Authors: Qian Zhao, Shan-Shan Xiong, Can Chen, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
multitarget drugs
histone deacetylase inhibitors
MDM2 inhibitors
spirooxindole
dual inhibitors
anticancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.972372/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.972372/full

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