Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury

Thioredoxin reductase 1 regulates hepatic inflammation and macrophage activation during acute cholestatic liver injury

Background and Aims:. Cholestatic liver diseases, including primary sclerosing cholangitis, are characterized by periportal inflammation with progression to hepatic fibrosis and ultimately cirrhosis. We recently reported that the thioredoxin antioxidant response is dysregulated during primary sclero...

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Bibliographic Details
Main Authors: Colin T. Shearn, Aimee L. Anderson, Colin G. Miller, Reed C. Noyd, Michael W. Devereaux, Nata Balasubramaniyan, David J. Orlicky, Edward E. Schmidt, Ronald J. Sokol
Format: Article
Language:English
Published: Wolters Kluwer Health/LWW 2023-01-01
Series:Hepatology Communications
Online Access:http://journals.lww.com/10.1097/HC9.0000000000000020

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http://journals.lww.com/10.1097/HC9.0000000000000020

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