The Presence of EGFR T790M in TKI-Naïve Lung Cancer Samples of Patients Who Developed a T790M-Positive Relapse on First or Second Generation TKI Is Rare

The Presence of EGFR T790M in TKI-Naïve Lung Cancer Samples of Patients Who Developed a T790M-Positive Relapse on First or Second Generation TKI Is Rare

EGFR-mutated non-small cell lung cancer (NSCLC) patients can be effectively treated with tyrosine kinase inhibitors (TKI) but frequently present with an EGFR T790M resistance mutation at relapse. We aimed to screen for T790M in pre-treatment formalin-fixed and paraffin-embedded (FFPE) tissue samples...

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Bibliographic Details
Main Authors: Weiting Li, Klaas Kok, Geok Wee Tan, Pei Meng, Mirjam Mastik, Naomi Rifaela, Frank Scherpen, T. Jeroen N. Hiltermann, Harry J. M. Groen, Anthonie J. van der Wekken, Anke van den Berg
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
NSCLC
EGFR
TKI
T790M
ddPCR
Online Access:https://www.mdpi.com/2072-6694/14/14/3511

Internet

https://www.mdpi.com/2072-6694/14/14/3511

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