Downregulated RBM5 Enhances CARM1 Expression and Activates the PRKACA/GSK3β Signaling Pathway through Alternative Splicing-Coupled Nonsense-Mediated Decay

Downregulated RBM5 Enhances CARM1 Expression and Activates the PRKACA/GSK3β Signaling Pathway through Alternative Splicing-Coupled Nonsense-Mediated Decay

Downregulated RNA-binding motif protein 5 (RBM5) promotes the development and progression of various tumors, including bladder cancer (BC). Alternative splicing (AS) plays a crucial role in the progression of cancer by producing protein isomers with different functions or by promoting nonsense-media...

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Bibliographic Details
Main Authors: Yanping Zhang, Fang Li, Zhenwei Han, Zhihai Teng, Chenggen Jin, Hao Yuan, Sihao Zhang, Kexin Sun, Yaxuan Wang
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
RBM5
CARM1
alternative splicing
nonsense-mediated mRNA decay
bladder cancer
Online Access:https://www.mdpi.com/2072-6694/16/1/139

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https://www.mdpi.com/2072-6694/16/1/139

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