Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation

Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation

Abstract As part of the central nervous system (CNS), retinal ganglion cells (RGCs) and their axons are the only neurons in the retina that transmit visual signals from the eye to the brain via the optic nerve (ON). Unfortunately, they do not regenerate upon injury in mammals. In ON trauma, retinal...

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Bibliographic Details
Main Authors: Mishal Rao, Yu-Kai Huang, Chia-Chun Liu, Chandler Meadows, Hui-Chun Cheng, Mengli Zhou, Yu-Chih Chen, Xin Xia, Jeffrey L. Goldberg, Andrew M. Williams, Takaaki Kuwajima, Kun-Che Chang
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-32702-5

Internet

https://doi.org/10.1038/s41598-023-32702-5

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