Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling

Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling

Abstract Background Ischemia-reperfusion (IR) induces increased release of extracellular vesicles in the heart and exacerbates myocardial IR injury. We have previously shown that propofol attenuates hypoxia/reoxygenation (HR)-induced injury in human umbilical vein endothelial cells (HUVECs) and that...

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Bibliographic Details
Main Authors: Xiaojun Zhang, Changsen Wang, Hao Xu, Shuyun Cai, Keyu Liu, Simeng Li, Linming Chen, Siman Shen, Xiaoxia Gu, Jing Tang, Zhengyuan Xia, Zhe Hu, Xiaotang Ma, Liangqing Zhang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Biological Research
Subjects:
Endothelial microvesicles (EMVs)
lncCCT4-2
Ischemia-reperfusion (IR)
Cardiomyocyte
Oxidative stress
Apoptosis
Online Access:https://doi.org/10.1186/s40659-023-00428-3

Internet

https://doi.org/10.1186/s40659-023-00428-3

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