Structural Analysis Implicates CASK-Liprin-α2 Interaction in Cerebellar Granular Cell Death in MICPCH Syndrome

Structural Analysis Implicates CASK-Liprin-α2 Interaction in Cerebellar Granular Cell Death in MICPCH Syndrome

Microcephaly with pontine and cerebellar hypoplasia (MICPCH) syndrome is a neurodevelopmental disorder caused by the deficiency of the X-chromosomal gene CASK. However, the molecular mechanisms by which CASK deficiency causes cerebellar hypoplasia in this syndrome remain elusive. In this study, we u...

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Bibliographic Details
Main Authors: Qi Guo, Emi Kouyama-Suzuki, Yoshinori Shirai, Xueshan Cao, Toru Yanagawa, Takuma Mori, Katsuhiko Tabuchi
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
MICPCH syndrome
CASK
Liprin-α2
cerebellar granule cells
CaMK domain
Online Access:https://www.mdpi.com/2073-4409/12/8/1177

Internet

https://www.mdpi.com/2073-4409/12/8/1177

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