Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration

Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration

Nogo receptor 1 (NgR1) mediates the inhibitory effects of several myelin-associated inhibitors (MAIs) on axonal regeneration in the central nervous system. A truncated soluble NgR1 (sNgR) has been reported to act as a decoy receptor to block the actions of MAIs. In this study, we fused the sNgR to n...

Full description

Bibliographic Details
Main Authors: Yi Zhang, Fangyou Gao, Dongsheng Wu, Pouria Moshayedi, Xinyu Zhang, Habib Ellamushi, John Yeh, John V. Priestley, Xuenong Bo
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Neurobiology of Disease
Subjects:
Nogo receptor
Nerve growth factor
Spinal cord injury
Axon regeneration
Lentiviral vector
Gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113001824

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113001824

Similar Items