Generation of an Obese Diabetic Mouse Model upon Conditional <i>Atrx</i> Disruption

Generation of an Obese Diabetic Mouse Model upon Conditional <i>Atrx</i> Disruption

Atrx loss was recently ascertained as insufficient to drive pancreatic neuroendocrine tumour (PanNET) formation in mice islets. We have identified a preponderant role of Atrx in the endocrine dysfunction in a <i>Rip-Cre;Atrx<sup>KO</sup></i> genetically engineered mouse model...

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Bibliographic Details
Main Authors: Tiago Bordeira Gaspar, Tito Teles Jesus, Maria Teresa Azevedo, Sofia Macedo, Mariana Alves Soares, Rui Sousa Martins, Rúben Leite, Lia Rodrigues, Daniela Ferreira Rodrigues, Luís Cardoso, Inês Borges, Sule Canberk, Fátima Gärtner, Leandro Miranda-Alves, José Manuel Lopes, Paula Soares, João Vinagre
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
Atrx
conditional mouse model
endocrine dysfunction
fatty pancreas
pancreatic fatty replacement
hyperglycaemia
Online Access:https://www.mdpi.com/2072-6694/15/11/3018

Internet

https://www.mdpi.com/2072-6694/15/11/3018

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