In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from <i>Salvia miltiorrhiza</i> as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

In Silico, In Vitro, and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from <i>Salvia miltiorrhiza</i> as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

Tanshinone IIA (TIIA) and cryptotanshinone (CRY) from <i>Salvia miltiorrhiza</i> Bunge were investigated for their inhibitory activity against the cyclooxygenase-2 (COX-2)/microsomal prostaglandin E synthase-1 (mPGES-1)/endothelial prostaglandin 3 (EP3) pathway using in silico, in vitro,...

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Bibliographic Details
Main Authors: Anella Saviano, Simona De Vita, Maria Giovanna Chini, Noemi Marigliano, Gianluigi Lauro, Gian Marco Casillo, Federica Raucci, Maria Iorizzi, Robert Klaus Hofstetter, Katrin Fischer, Andreas Koeberle, Oliver Werz, Francesco Maione, Giuseppe Bifulco
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomolecules
Subjects:
docking
EPs
mPGES-1
platelet aggregation
tanshinones
Online Access:https://www.mdpi.com/2218-273X/12/1/99

Internet

https://www.mdpi.com/2218-273X/12/1/99

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