Effect of particle size on biological response by human monocyte-derived macrophages

Ultra-high molecular weight polyethylene (UHMWPE) wear particles from artificial joints induce osteolysis and the subsequent loosening of implants. Studies have reported that particles in the size range of 0.1–10 μm are the most biologically active in macrophage immune response. To develop prostheti...

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Bibliographic Details
Main Authors: H. Chikaura, Y. Nakashima, Y. Fujiwara, Y. Komohara, M. Takeya, Y. Nakanishi
Format: Article
Language:English
Published: Wiley 2016-03-01
Series:Biosurface and Biotribology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405451816000040