Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6

Collagen VI Is a Gi-Biased Ligand of the Adhesion GPCR GPR126/ADGRG6

GPR126/ADGRG6, a member of the adhesion G-protein-coupled receptor family, balances cell differentiation and proliferation through fine-tuning of intracellular cAMP levels, which is achieved through coupling to Gs and Gi proteins. While GPR126-mediated cAMP increase has been proven to be essential f...

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Bibliographic Details
Main Authors: Caroline Wilde, Paulomi Mehta Chaudhry, Rong Luo, Kay-Uwe Simon, Xianhua Piao, Ines Liebscher
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
adhesion GPCR
GPR126
ADGRG6
biased signaling
extracellular matrix ligand
collagen VI
Online Access:https://www.mdpi.com/2073-4409/12/11/1551

Internet

https://www.mdpi.com/2073-4409/12/11/1551

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