A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation

A potent trypanocidal component from the fungus Lentinus strigosus inhibits trypanothione reductase and modulates PBMC proliferation

The fungus Lentinus strigosus (Pegler 1983) (Polyporaceae, basidiomycete) was selected in a screen for inhibitory activity on Trypanosoma cruzi trypanothione reductase (TR). The crude extract of L. strigosus was able to completely inhibit TR at 20 µg/ml. Two triquinane sesquiterpenoids (dihydrohypno...

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Bibliographic Details
Main Authors: Betania Barros Cota, Luiz Henrique Rosa, Elaine Maria Souza Fagundes, Olindo Assis Martins-Filho, Rodrigo Correa-Oliveira, Alvaro José Romanha, Carlos Augusto Rosa, Carlos Leomar Zani
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2008-05-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
fungal natural products
Chagas disease
drug discovery
immunomodulators
Basidiomycota
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000300007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000300007

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