CPEB2 m6A methylation regulates blood–tumor barrier permeability by regulating splicing factor SRSF5 stability
The methyl transferase METTL3 is up-regulated in brain tumors leading to the methylation of CPEB2 mRNA, which in turn stabilizes the splicing factor SRSF5 mRNA, leading to the incorporation of exon 7 in ETS-1 in models of the Blood–Tumor Barrier.
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-022-03878-9 |