The autism spectrum disorder risk gene NEXMIF over-synchronizes hippocampal CA1 network and alters neuronal coding

The autism spectrum disorder risk gene NEXMIF over-synchronizes hippocampal CA1 network and alters neuronal coding

Mutations in autism spectrum disorder (ASD) risk genes disrupt neural network dynamics that ultimately lead to abnormal behavior. To understand how ASD-risk genes influence neural circuit computation during behavior, we analyzed the hippocampal network by performing large-scale cellular calcium imag...

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Bibliographic Details
Main Authors: Rebecca A. Mount, Mohamed Athif, Margaret O’Connor, Amith Saligrama, Hua-an Tseng, Sudiksha Sridhar, Chengqian Zhou, Emma Bortz, Erynne San Antonio, Mark A. Kramer, Heng-Ye Man, Xue Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Neuroscience
Subjects:
autism spectrum disorder
network analysis
E/I balance
functional connectivity
network closeness centrality
pairwise correlation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1277501/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1277501/full

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