Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma

Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma

Abstract Background Pilomyxoid astrocytomas are an aggressive subtype of astrocytoma, not graded by WHO, frequently located in hypothalamic/chiasmatic region, affecting diencephalic structures, and characterized by shorter survival and high recurrence rates. Pilomyxoid astrocytoma management remains...

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Bibliographic Details
Main Authors: Elena I. Fomchenko, Benjamin C. Reeves, William Sullivan, Asher M. Marks, Anita Huttner, Kristopher T. Kahle, E. Zeynep Erson‐Omay
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
FGFR inhibitor resistance
FGFR1 mutation
FGFR1 p.K656E
FGFR1 p.V561M
pilomyxoid astrocytoma
whole exome sequencing
Online Access:https://doi.org/10.1002/mgg3.1597

Internet

https://doi.org/10.1002/mgg3.1597

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