Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction

Differences in Expression of Mitochondrial Complexes Due to Genetic Variants May Alter Sensitivity to Radiation-Induced Cardiac Dysfunction

Radiation therapy is received by over half of all cancer patients. However, radiation doses may be constricted due to normal tissue side effects. In thoracic cancers, including breast and lung cancers, cardiac radiation is a major concern in treatment planning. There are currently no biomarkers of r...

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Bibliographic Details
Main Authors: Rachel A. Schlaak, Anne Frei, Gopika SenthilKumar, Shirng-Wern Tsaih, Clive Wells, Jyotsna Mishra, Michael J. Flister, Amadou K. S. Camara, Carmen Bergom
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
radiation
radiation-induced heart damage
mitochondria
consomic rats
oxidative phosphorylation
echocardiogram
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2020.00023/full

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https://www.frontiersin.org/article/10.3389/fcvm.2020.00023/full

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