Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Sufficient colonic absorption is necessary for all systemically acting drugs in dosage forms that release the drug in the large intestine. Preclinically, colonic absorption is often investigated using the rat single-pass intestinal perfusion model. This model can determine intestinal permeability ba...

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Bibliographic Details
Main Authors: David Dahlgren, Maria-Jose Cano-Cebrián, Tobias Olander, Mikael Hedeland, Markus Sjöblom, Hans Lennernäs
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Pharmaceutics
Subjects:
regional intestinal permeability
permeation enhancers
absorption-modifying excipients
oral peptide delivery
intestinal perfusion
pharmaceutical development
Online Access:https://www.mdpi.com/1999-4923/12/3/242

Internet

https://www.mdpi.com/1999-4923/12/3/242

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