Abnormal DNA methylation in pluripotent stem cells from a patient with Prader-Willi syndrome results in neuronal differentiation defects

Abnormal DNA methylation in pluripotent stem cells from a patient with Prader-Willi syndrome results in neuronal differentiation defects

DNA methylation is a common method of gene expression regulation, and this form of regulation occurs in the neurodevelopmental disorder Prader-Willi syndrome (PWS). Gene expression regulation via methylation is important for humans, although there is little understanding of the role of methylation i...

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Bibliographic Details
Main Authors: Shuhei Soeda, Ryo Saito, Ai Fujii, Shusei Tojo, Yuka Tokumura, Hideo Taniura
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Stem Cell Research
Subjects:
Prader-Willi syndrome
DNA methylation
Embryoid body
Neural stem cell
Neuronal differentiation
iPS cells
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506121001975

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http://www.sciencedirect.com/science/article/pii/S1873506121001975

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