GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice

Abstract Background Female mammals have a limited reproductive lifespan determined by the size of the primordial follicle pool established perinatally. Over two thirds of fetal oocytes are abolished via programmed cell death during early folliculogenesis. However, the underlying mechanisms governing...

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Bibliographic Details
Main Authors: Jia Wen, Hao Yan, Meina He, Tuo Zhang, Xinyi Mu, Haibin Wang, Hua Zhang, Guoliang Xia, Chao Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Biology
Subjects:
DNA damage checkpoint
GSK-3β
Meiotic prophase I
Oocytes
Primordial follicle
Online Access:http://link.springer.com/article/10.1186/s12915-019-0641-9

Internet

http://link.springer.com/article/10.1186/s12915-019-0641-9

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