An insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine

An insight review on the neuropharmacological effects, mechanisms of action, pharmacokinetics and toxicity of mitragynine

Mitragynine is one of the main psychoactive alkaloids in Mitragyna speciosa Korth. (kratom). It has opium-like effects by acting on μ-, δ-, and κ-opioid receptors in the brain. The compound also interacts with other receptors, such as adrenergic and serotonergic receptors and neuronal Ca2+ channels...

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Bibliographic Details
Main Authors: Nur Aisyah Khairul Annuar, Ummi Kalthum Azlan, Ahmed Mediani, Xiaohui Tong, Rongchun Han, Ebtesam Al-Olayan, Syarul Nataqain Baharum, Hamidun Bunawan, Murni Nazira Sarian, Hamizah Shahirah Hamezah, Ibrahim Jantan
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Mitragyna speciosa
Mitragynine
Pharmacological properties
Toxicity
Molecular mechanisms
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000155

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http://www.sciencedirect.com/science/article/pii/S0753332224000155

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