Dysregulated Cardiac IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity

Dysregulated Cardiac IGF-1 Signaling and Antioxidant Response Are Associated with Radiation Sensitivity

Acute exposure to ionizing radiation leads to Hematopoietic Acute Radiation Syndrome (H-ARS). To understand the inter-strain cellular and molecular mechanisms of radiation sensitivity, adult males of two strains of minipig, one with higher radiosensitivity, the Gottingen minipig (GMP), and another s...

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Bibliographic Details
Main Authors: Saeed Y. Aghdam, Doreswamy Kenchegowda, Neel K. Sharma, Gregory P. Holmes-Hampton, Betre Legesse, Maria Moroni, Sanchita P. Ghosh
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
radiation
IGF-1
cardiovascular
Nrf2
Redox status
Online Access:https://www.mdpi.com/1422-0067/21/14/5049

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https://www.mdpi.com/1422-0067/21/14/5049

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