Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer

Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer

Abstract Background Recently, we reported that tamoxifen-resistant (TAM-R) breast cancer cells are cross-resistant to irradiation. Here, we investigated the mechanisms associated with tamoxifen-induced radioresistance, aiming to prevent or reverse resistance and improve breast cancer treatment. Meth...

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Bibliographic Details
Main Authors: F. V. Naumann, F. C. G. J. Sweep, G. J. Adema, W. J. M. Peeters, J. W. M. Martens, J. Bussink, P. N. Span
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cancer & Metabolism
Subjects:
Tamoxifen
Radiotherapy
Breast cancer
Reactive oxygen species
Antioxidants
NRF2
Online Access:https://doi.org/10.1186/s40170-023-00304-4

Internet

https://doi.org/10.1186/s40170-023-00304-4

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